FADA — Candida albicans

Summary

C3_02240C_A (FADA, also known as GPA2) on Candida albicans chromosome 3 encodes a G-protein alpha subunit, a member of the fungal G-protein family with GTPase activity, GTP binding, and adenylate cyclase activator activity. This gene is associated with GPCR signaling, the glucose-sensing PKA pathway, quorum sensing, filamentous growth in response to heat and neutral pH, invasive growth under heat and glucose limitation, cellular copper ion homeostasis, immune evasion, and pheromone response. It localizes to the heterotrimeric G-protein complex and cytoplasm. Phenotypic associations link the gene to altered mating efficiency, pheromone production and sensitivity, cell cycle progression, budding rate, nuclear size, pexophagy, mitotic recombination, and sporulation timing. Studies of related genes in other species connect the family to virulence and pathogenicity.