CDC25 — Candida albicans

Summary

C3_03890W_A (CDC25, also known as CSC25) in Candida albicans encodes a protein with Ras guanine nucleotide exchange factor (RasGEF) domains and an SH3 domain. The gene product is associated with Ras protein signal transduction, the adenylate cyclase-activating GPCR signaling pathway, and positive regulation of the pheromone response MAPK cascade. It is linked to cell cycle control, including traversing the start control point of mitosis, upregulation of exit from mitosis, and cytokinesis, as well as protein localization to the mitotic spindle. CDC25 is associated with biofilm formation, filamentous growth in response to starvation, conjugation with cellular fusion, and establishment or maintenance of cell polarity. The protein localizes to the plasma membrane, cytoplasm, cytosol, and cellular bud. Phenotypic associations include increased adhesion, altered cell cycle progression, increased thermotolerance, increased mating efficiency, and abnormal spore germination. Studies of related genes in other species link the family to protein content traits.