WOR2 — Candida albicans

Summary

C3_05170W_A (WOR2) in Candida albicans chromosome 3 encodes a Zn2Cys6 DNA-binding transcription factor with RNA polymerase II-specific regulatory activity, also annotated as a protein membrane adaptor with phosphatidylinositol-3-phosphate binding. The gene is associated with phenotypic switching, biofilm formation, mating, and both positive and negative regulation of transcription by RNA polymerase II. It is linked to growth as a thread of attached cells, negative regulation of that growth, and biological processes involved in symbiotic interaction. Associations also include glycophagy, ER-phagy, mitochondrial autophagy, lipid and protein transport, and galactose-specific flocculation along with its negative regulation. The product localises to the nucleus, chromatin, mating-type region heterochromatin, centric heterochromatin, the ER membrane, the phagophore, and the pre-autophagosomal structure membrane. Studies of related genes in other species connect the family to autophagic processes.