CKI1 — Candida albicans

Summary

CKI1 (YCK2) on Candida albicans chromosome 3 encodes a member of the CK1 Ser/Thr kinase family, with protein serine/threonine kinase activity, protein tyrosine kinase activity, and ATP and magnesium binding. The gene is associated with regulation of filamentous growth, biofilm formation, cell wall organization, endocytosis, and maintenance of cell polarity, as well as response to glucose, cellular stress, and interaction with host. It has been linked to downregulation of bipolar cell polarity and protein localisation to cell tip, and to arginine breakdown, demethylation, the glyoxylate cycle, and the TCA cycle. The product localises to the cytoplasm, nucleus, plasma membrane, cell tip, cell division site, vacuolar lumen and membrane, and extracellular vesicles. Associations include abnormal vacuolar and Golgi morphology, decreased intracellular transport, premature G2/M transition, increased shmoo formation, and absent biofilm formation and osmotic stress resistance.