KRE6 — Candida albicans

Summary

C3_05830W_A (KRE6, CaSKN1) in Candida albicans encodes a GH16 family protein with glucosidase activity, localised to the Golgi and ER membranes and the plasmalemma. It is associated with cell wall organisation or biogenesis, including fungal-type cell wall beta-glucan and 1,6-beta-glucan anabolism, as well as chitin and ergosterol anabolism. The gene is linked to hyphal growth, morphogenesis, biofilm formation, and regulation of cytoskeleton organisation. Associations with cell cycle progression, including G2/M phase transition and M phase duration, cytokinesis rate, and thermotolerance have been noted. Additional connections include abnormal filamentous growth, decreased endocytosis, increased hydrostatic pressure resistance, and altered nuclear fusion during mating. Studies of related genes in other species link the family to reduced virulence and acid sensitivity.