OS-5 — Candida albicans

Summary

C3_06070C_A (OS-5, PBS2) in Candida albicans encodes a dual-specificity protein kinase with MAP kinase scaffold activity, MAPKK activity, and Nalpha-acetyltransferase activity, containing a protein kinase domain. This gene is associated with multiple MAPK cascades, including the cell integrity, pheromone response, osmosensory Sho1, and SAPK signaling pathways, as well as p38 cascade, quorum sensing, filamentous growth signal transduction, and regulation of ascospore and appressorium formation. It is linked to cellular processes such as glycerol anabolism, lipid oxidation, actin filament organization, and calcium-mediated signaling. Localization evidence places the product at the NatB complex, Mcs4 RR-MAPKKK complex, cellular bud tip, mating projection tip, division septum, and bud neck. Phenotypic associations include increased acquired thermotolerance, increased sporulation and fermentative growth, increased adhesion and pexophagy, altered cell cycle progression, and absence of mating efficiency, hyperosmotic stress resistance, and desiccation resistance.