OGM2 — Candida albicans

Summary

C3_06890W_A (OGM2/PMT2) on Candida albicans chromosome 3 encodes a protein O-mannosyltransferase (EC 2.4.1.109) with protein O-mannosyltransferase activity, mannosyltransferase activity, transglycosidase activity, and identical protein binding. This enzyme is associated with protein O-linked glycosylation, mannan anabolism, fungal-type cell wall organization, filamentous growth in response to neutral pH and starvation, biofilm formation, cell-substrate adhesion, interaction with host, immune response, cytokine production, regulation of ER UPR, downregulation of proteolysis, protein secretion, and cellular response to neutral pH and starvation. It localizes to the ER membrane, nuclear membrane, endomembrane system, plasma membrane, and as part of a dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer. The gene is linked to candidiasis and mannose content, and related genes in other species are associated with loss of pathogenicity and unaffected pathogenicity.