MRR2 — Candida albicans

Summary

MRR2 (C3_07860C_A) in Candida albicans encodes a Zn2Cys6 fungal-type transcription factor with DNA-binding transcription factor activity specific for RNA polymerase II. The protein localises to both the nucleus and membrane. MRR2 is associated with positive regulation of cellular response to drug, biofilm formation, filamentous growth, invasive growth, cell-substrate adhesion, and interaction with host. It has also been linked to cellular responses to oxidative stress and xenobiotic stimulus, autophagy, and regulation of transcription by RNA polymerase II. Studies of related genes in other species connect the MRR2 family to reduced virulence and disseminated candidiasis.