AMT1 — Candida albicans

Summary

AMT1 (also known as MEP2, CaAMT1, and CaMEP2) on Candida albicans chromosome 4 encodes an ammonium transporter family protein with ammonium channel activity and methylammonium transmembrane transporter activity. This gene is associated with ammonium and methylammonium membrane transport, nitrogen utilization, and cellular responses to nitrogen starvation. AMT1 is linked to the regulation of morphogenesis, including filamentous growth and pseudohyphal growth in response to starvation, as well as biofilm formation, flocculation, cell-cell adhesion, and TOR signaling. It is associated with abnormal biofilm formation, increased virulence, altered cell cycle progression, abnormal autophagy, and decreased nitrogen source utilization. The protein localizes to the plasma membrane, Golgi complex, and fungal-type vacuole. Related genes in other species link the family to protein and phosphate content.