FBA — Candida albicans

Summary

C4_01750C_A (FBA1) encodes a class II fructose-bisphosphate aldolase, a glycolytic enzyme that also binds melatonin and zinc. In Candida albicans, FBA1 is associated with canonical glycolysis, gluconeogenesis, and the glycolytic process, as well as with methylglyoxal and oligosaccharide anabolism, GPI anchor and glucan biosynthesis, and mRNA breakdown. It is linked to intestinal absorption, opsonization, clotting, memory, inflammatory response, and GMP anabolism. The gene is associated with host interaction, including perturbation of host immune response, and with cell adhesion, response to oxidative stress, and hyphal cell wall localization. Phenotypic associations include altered fermentative metabolism, cell death, adhesion, nutrient uptake, cell size, cytokinesis, septum formation, cold sensitivity, and replicative lifespan. Studies of related genes in other species link the family to germination rate and decreased exponential-phase growth.