ECE1 — Candida albicans

Summary

C4_03470C_A (ECE1) in Candida albicans chromosome 4 encodes a protein with membrane destabilizing activity, toxin activity, and glycosaminoglycan binding. The gene is associated with hemolysis in other organisms, cytolysis of host cells, disruption of host mucosa, and receptor breakdown. It is linked to inflammatory response, IL-8 production, and response to host, as well as to germ tube formation, cell motility, cell aggregation, and cell activation. Associations also include alternative respiration, ceramide and cysteine anabolism, seed growth and germination, and response to symbiotic bacteria. The protein localizes to the host cell plasma membrane, hyphal cell wall, and extracellular. ECE1 is connected to vulvovaginal, oral, oropharyngeal, and disseminated candidiasis, and to oxidative stress response.