LYS2 — Candida albicans

Summary

C4_04410C_A (LYS2, also known as LYS4) in Candida albicans encodes a homoaconitate hydratase (EC 4.2.1.36), an enzyme that contains a 4Fe-4S cluster and localises to the mitochondrial lumen. The gene is associated with lysine and amino acid biosynthesis, and with filamentous growth. Phenotypic associations link LYS2 to abnormal mitochondrial transport and genome maintenance, decreased mitophagy, pexophagy and reticulophagy, increased apoptosis and mitotic recombination, altered pseudohyphal growth, reduced biofilm formation, sporulation, respiratory growth and nutrient utilisation, and increased stress and metal resistance. Related genes in other species are linked to endocytosis and vacuolar morphology, and to iron-sulfur cluster assembly.