GYP2 — Candida albicans

Summary

Candida albicans gene C4_05600W_A (symbol GYP2, also known as MDR1 or CaMDR1) on chromosome 4 encodes a protein with GTPase-activating protein (GAP) activity and calcium ion binding capacity, containing GRAM, Rab-GAP-TBC, EF-hand, and PH-like domains. The gene is associated with diverse biological processes including fluconazole transport, ergosterol metabolism, germ tube formation, quorum sensing, phagocytosis, immune response, nitrogen utilization, mRNA transcription, phospholipid transport, and response to ethanol. The encoded protein localizes to the plasma membrane, Golgi-associated vesicles, sites of polarized growth, mating projection tips, cell division sites, cytoplasm, cytosol, and nucleus. GYP2 is linked to numerous phenotypes including abnormal endocytosis, autophagy, protein transport, cell morphology, budding pattern, chitin deposition, cytokinesis, and decreased resistance to chemicals and alkaline pH. Studies of related genes in other species connect the family to intracellular transport and secretion processes.