PHO4 — Candida albicans

Summary

C4_05680W_A (PHO4) on Candida albicans chromosome 4 encodes a basic helix-loop-helix (bHLH) protein with sequence-specific DNA binding, protein dimerization activity, and RNA polymerase II-specific transcription factor activity. The gene is associated with the nucleus and RNA polymerase II transcription regulator complexes. It is linked to cellular response to phosphate starvation, intracellular Pi homeostasis, polyphosphate anabolism, phosphate metabolism, oxygen metabolism, electron transport chain, cellular response to arsenic, cellular response to copper, cellular monoatomic cation homeostasis, lipid metabolism, DNA replication, phenotypic switching, sexual reproduction, mating, filamentous growth, and regulation of transcription by RNA polymerase II. The gene has been associated with systemic candidiasis and studies in Galleria mellonella.