PRA1 — Candida albicans

Summary

C4_06980W_A (PRA1, also known as ASPF2, CaZPS1, CaASPF2, ZPS1) on Candida albicans chromosome 4 encodes a PRA1-like metallopeptidase with a MetalloPept_cat_dom_sf domain and HRXXH motif, exhibiting integrin, fibrinogen, and HK binding activities as well as zinc binding and metallopeptidase activity. The gene is associated with adhesion of symbiont to host extracellular matrix, iron acquisition from host, and zinc import and response. It is linked to regulation of innate immune response, neutrophil activation and migration, NK cell activation, and suppression of host complement activation and T-cell-mediated immune response. Localization evidence connects PRA1 to the hyphal tip, hyphal cell wall, fungal-type cell wall, and extracellular. The gene is also associated with protein content and oxidative stress response traits. Studies of related genes in other species link the family to altered innate thermotolerance and vegetative growth.