PRR1 — Candida albicans

Summary

C5_00240W_A (PRR1, also known as SKN7) in Candida albicans encodes a phosphorelay response regulator with DNA-binding transcription activator activity, RNA polymerase II-specific, and transferase activity. The protein contains a signal transduction response regulator receiver domain, an HSF-type DNA-binding domain, and a CheY-like receiver domain. PRR1 is associated with the biological processes of histidyl-aspartyl phosphorelay, quorum sensing, response to singlet oxygen, cellular thermotolerance, aerobic respiration, gluconeogenesis, hexose breakdown, iron transport, host invasion, immune evasion, and regulation of filamentous growth in response to starvation and biotic stimuli. It localizes to the nucleus, cytoplasm, chromatin, and RNA polymerase II transcription regulator complex. The gene is linked to traits including oxidative stress response and response to pH, and to phenotypes such as absent oxidative stress resistance, absent biofilm formation, abnormal flocculation, increased thermotolerance, increased adhesion, increased mating efficiency, and altered cell cycle progression.