KRE6 — Candida albicans

Summary

C5_00470C_A (KRE6, also known as KRE62) in Candida albicans encodes a glucosidase belonging to the GH16 family and containing a ConA-like domain. The gene is associated with cell wall organization or biogenesis, including 1,6-beta-glucan and chitin anabolism, as well as cell wall assembly. It is linked to the regulation of cytoskeleton organization, hyphal growth, biofilm formation, morphogenesis, and ergosterol anabolism. The encoded protein localizes to the Golgi membrane, endoplasmic reticulum membrane, and plasma membrane. Phenotypic associations include abnormal cell cycle progression, increased thermotolerance, decreased endocytosis, abnormal filamentous growth, and increased polyploidy. Studies of related genes in other species link the family to beta-glucan synthesis and, in some cases, to loss of pathogenicity or reduced virulence.