CLN3 — Candida albicans

Summary

C5_01100C_A (CLN3) on chromosome 5 of Candida albicans encodes a cyclin CLN family protein with cyclin-box and cyclin-N domains, and is annotated with cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activity. The gene is associated with regulation of G1/S transition of the mitotic cell cycle, cell budding, quorum sensing, maintenance of cell polarity, development of symbiont in host, and positive regulation of filamentous growth, including upregulation in response to pH. It is also linked to ROS metabolic processes, amino acid breakdown, glycolytic processes, and negative regulation of cell cycle switching from mitotic to meiotic. The product localizes to the nucleus, cytoplasm, cytosol, microtubule-organizing center, and CDK holoenzyme complex. Studies of related genes in other species connect the family to altered virulence, including hypervirulence and reduced virulence, as well as to candidiasis.