ASPA — Candida albicans

Summary

C5_00070W_A (ASPA, also known as CDC11) in Candida albicans encodes a septin family protein containing a G_SEPTIN domain and P-loop NTPase domain, with GTPase activity and structural constituent of cytoskeleton function. It binds phosphatidylinositol phosphates and exhibits identical protein binding and bridging activities. This gene is associated with cytoskeleton-dependent cytokinesis, septin ring assembly and disassembly, contractile ring assembly, division septum assembly, and mitotic actomyosin contractile ring organization. It is linked to regulation of morphogenesis, maintenance of cell polarity, ER polarization, chitin localization, quorum sensing, and adhesion of symbiont to host. The protein localizes to the septin cytoskeleton, bud neck septin structure, hyphal septin ring, and mitotic septin complex. Associations include cell cycle progression through G2/M phase transition, chromosome segregation, and resistance to chemicals. Related genes in other species link the family to telomere length maintenance and prion inheritance.