DDR48 — Candida albicans

Summary

CaDDR48 (C4_07130W_A, DDR48) on Candida albicans chromosome 4 encodes a stress-responsive protein of the FSP/HIS4-related family. The gene is associated with IMP anabolism, glutathione metabolism, sterol and ergosterol anabolism, and protein synthesis. It is linked to biofilm formation, flocculation, hyphal growth, morphogenesis, homologous recombination, DNA repair, the DNA damage response, and cell death. Associations with oxidative stress response and increased heat sensitivity, decreased vegetative growth, decreased chemical resistance, abnormal nucleolar morphology, and altered prion formation and loss have been observed. Studies of related genes in other species link the family to increased metal resistance, decreased hyperosmotic stress and starvation resistance, and abnormal vacuolar morphology.