CSA2 — Candida albicans

Summary

C4_06920C_A (CSA2) in Candida albicans chromosome 4 encodes a CFEM domain-containing protein with heme and metal binding capabilities. The gene is associated with hemoglobin uptake, heme membrane transport, cellular iron ion homeostasis, and sulfur metabolism. It has been linked to biofilm formation, including cell adhesion involved in single-species biofilm formation and biofilm formation on inanimate substrates, as well as hyphal growth, sporulation, secretion, programmed cell death, and membrane transport. The product localizes to the fungal-type cell wall, yeast-form and hyphal cell walls, cellular bud, side of membrane, plasmalemma, and extracellular. Studies of related family members in other species link the CFEM protein family to reduced virulence and disseminated candidiasis.