CAT1 — Candida albicans

Summary

Candida albicans GAP5 (CAT1, C4_05430C_A) encodes an amino acid permease with L-arginine and L-lysine transporter activity. This gene is associated with regulation of growth, germ tube formation, and cell-cell signaling, as well as responses to stress, glutathione, and iron. It has been linked to nitrogen catabolite repression, nitrogen utilization, amino acid import, phospholipid transport, glycan biosynthesis, metabolic burst, circadian rhythm, wound healing, and SAM transport. The protein localizes to the plasma membrane, cell tip, Golgi membrane, extracellular vesicles, and the fungal cell wall. Phenotypic associations include altered nutrient uptake, cell cycle progression, endocytosis, adhesion, sporulation, spore germination, replicative lifespan, and responses to hydrostatic pressure and chemical compounds. Studies of related genes in other species link the family to phosphate content.