PP2A — Candida albicans

Summary

C4_05050C_A (PP2A, also known as PPG1, CaPPA3, or CaPPG1) on chromosome 4 of Candida albicans encodes a protein with a PPA2-like domain, a Ser/Thr-specific protein phosphatase domain, a calcineurin-like PHP domain, and a metallo-dependent phosphatase-like domain, and is annotated with protein phosphatase activity, protein serine/threonine phosphatase activity (EC 3.1.3.16), O-glucosyl hydrolase activity, and metal binding. The gene is associated with protein dephosphorylation, negative regulation of mitophagy and DNA damage checkpoint, positive regulation of NHEJ, regulation of TORC1 signaling, and responses to host and chemical stimuli. It localizes to the PP2A and protein phosphatase 4 complexes, nucleus, cytoplasm, mitochondrial outer membrane, and mitotic spindle pole body. Phenotypic associations include abnormal cell cycle progression, decreased pheromone sensitivity, decreased ionic stress resistance, increased mitophagy, and decreased protein secretion. Studies of related genes in other species link the family to acid sensitivity and candidiasis.