CPP1 — Candida albicans

Summary

C4_03900C_A (CPP1, also known as RAM1) in Candida albicans encodes a protein with FTB, PFTB repeat, PGGT1B-like, and Terpenoid_cyclase/PrenylTrfase domains, and is annotated with protein farnesyltransferase, GGTaseI and GGTaseII activities, small GTPase binding, and zinc and metal binding. It is a component of the protein farnesyltransferase, CAAX-protein geranylgeranyltransferase, and GGTase-II complexes, localizing to the cytoplasm, cytosol and nucleus. The gene is associated with protein prenylation, farnesylation and geranylgeranylation, establishment of protein localization to the plasma membrane, regulation of DNA replication, chlamydospore formation, MAPK cascade, cell wall biogenesis, pheromone response, and phospholipid and thiamin anabolism. Phenotypic associations link CPP1 to mating efficiency, pheromone production and sensitivity, pseudohyphal growth, cell cycle progression, apoptosis, lifespan, vegetative growth, acquired thermotolerance, mitophagy, pexophagy, chitin deposition, spore wall formation, and nuclear import and position.