AIM2 — Candida albicans

Summary

CaAIM2 (C4_01800W_A) in Candida albicans encodes a protein containing an AB hydrolase domain and a dienelactone hydrolase domain, with hydrolase activity annotated as its molecular function. The gene is associated with antimicrobial peptide secretion, type I IFN production, IL-17 production, IL-1 production, inflammatory response, immune response, cell death, autophagy, memory, and secretion. It localizes to both the cytosol and nucleus. Phenotypic associations include decreased vegetative growth rate, altered carbon source utilization, decreased heat sensitivity, altered oxidative stress resistance, abnormal vacuolar morphology, and changes in competitive fitness. Studies of related genes in other species link the family to decreased filamentous growth and absent invasive growth, though these are not established for CaAIM2 itself.