HAP5 — Candida albicans

Summary

C4_02630C_A (HAP5, also known as HFL2) in Candida albicans encodes a protein with a histone-fold domain and CBFA_NFYB domain, and is annotated with core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, chromatin binding, transcription coactivator and corepressor activities, and TBP-class protein binding. The gene is associated with regulation of transcription by RNA polymerase II, including positive regulation and preinitiation complex assembly, as well as filamentous growth, morphogenesis, cellular response to heat, regulation of aerobic respiration, the TCA cycle, response to iron, siRNA-mediated heterochromatin formation, and NO storage. It localizes to the nucleus, cytoplasm, chromatin, and the negative cofactor 2 complex. Phenotypic associations link HAP5 to altered respiratory and fermentative metabolism, increased osmotic stress resistance, increased acid pH resistance, increased survival in stationary phase, increased apoptosis, decreased pseudohyphal growth, and abnormal cell cycle progression, chromosome segregation, and nuclear position.