BGL2 — Candida albicans

Summary

Candida albicans BGL2 (CaBGL2, C4_02250C_A) encodes a glycoside hydrolase family 17 protein with glucanosyltransferase, glucan exo-1,3-beta-glucosidase, and glucan endo-1,3-beta-D-glucosidase activities. The gene is associated with fungal-type cell wall beta-glucan metabolism, cell wall assembly and organization, biofilm formation, adhesion to host, host invasion, immune response and evasion, and exocytosis. It is linked to the yeast-form cell wall, fungal-type cell wall, extracellular vesicles, and plasma membrane. Phenotypic associations include abnormal cell wall morphology, decreased adhesion, absent filamentous and pseudohyphal growth, increased biofilm formation, altered chitin deposition, increased alkaline and acid pH resistance, increased vegetative growth, and increased mating response. Studies of related genes in other species link BGL2 to exo-1,3-beta-glucanase activity and biomass yield.