BSC1 — Candida albicans

Summary

C4_00760W_A (BSC1, ZCF21) on Candida albicans chromosome 4 encodes a Zn2Cys6 DNA-binding domain transcription factor with DNA-binding transcription repressor activity, RNA polymerase II-specific. The gene is associated with biofilm formation, flocculation, cell adhesion, mating, fermentation, pheromone response, response to oxidative stress, fungal-type cell wall biogenesis, ergosterol and sterol metabolism, secretion, and telomere localization. It is linked to abnormal biofilm formation, absent flocculation, increased adhesion, increased mating efficiency, decreased budding rate, delayed cytokinesis, premature meiosis, increased polyploidy, decreased cell death, and absent toxin and osmotic stress resistance. The gene product localizes to the nucleus and is associated with regulation of growth of a unicellular organism as a thread of attached cells and negative regulation of transcription by RNA polymerase II.