HIS3 — Candida albicans

Summary

Candida albicans HIS3 (also known as HIS5) on chromosome 4 encodes a histidinol-phosphate transaminase (EC 2.6.1.9), a pyridoxal phosphate-dependent enzyme of the aminotransferase family. The gene is associated with histidine anabolism, as well as with immune response, phenotypic switching, biofilm formation, cell cycle, mitosis, nuclear division, spindle assembly, and homeostasis. It is linked to numerous phenotypes including increased stress resistance, metal resistance, replicative and chronological lifespan, competitive fitness, and altered mitochondrial transport, pexophagy, reticulophagy, mitophagy, respiratory growth, starvation resistance, and nitrogen utilization. The gene product localizes to the cytosol. Studies of related genes in other species link the family to oxidative stress response, mitotic recombination, endocytosis, and vacuolar morphology.