PGA10 — Candida albicans

Summary

PGA10 (C4_00450C_A) in Candida albicans chromosome 4 encodes a CFEM domain-containing extracellular membrane protein. The product binds heme and metal ions, and is associated with hemoglobin uptake, heme membrane transport, cellular iron ion homeostasis, and response to hypoxia. It is also linked to biofilm formation, cell adhesion, hyphal and filamentous growth, secretion, and ergosterol anabolism. The protein localizes to the cell wall, plasma membrane, cellular bud, and extracellular space. Studies of related genes in other species link the family to reduced virulence and disseminated candidiasis in mouse models. The gene is also associated with relative growth rate.