CYS3 — Candida albicans

Summary

C4_00200C_A (CYS3, also known as MET15) in Candida albicans encodes a pyridoxal phosphate-dependent enzyme with O-acetylhomoserine (thiol)-lyase, homocysteine synthase, and cysteine-S-conjugate β-lyase activities (EC 2.5.1.49, 2.5.1.47). The gene is associated with the biosynthesis of cysteine, homocysteine, methionine, and glutathione, as well as with transsulfuration, sulfate assimilation, glutathione transport and breakdown, and alkaloid metabolism. It has been linked to hyphal cell wall, peroxisomal, extracellular, cytoplasmic, cytosolic, and nuclear localisation. Phenotypic associations include abnormal nutrient utilization, altered sulfur source utilization, increased X-ray and UV resistance, increased aneuploidy, increased meiotic recombination, increased entry into G0, increased critical cell size at the G1 checkpoint, decreased colony size, absent filamentous growth, and abnormal cell cycle progression, nucleophagy, mitophagy, and silencing. Studies of related genes in other species link the family to oxidative stress response.