CYC8 — Candida albicans

Summary

C3_07020W_A (CYC8, also known as SSN6) in Candida albicans encodes a corepressor-demethylase family protein with TPR repeats. The gene product binds chromatin DNA and histone deacetylase, and exhibits both transcription coactivator and corepressor activities, as well as RNA polymerase II cis-regulatory region sequence-specific DNA binding. CYC8 is associated with filamentous growth, hyphal growth, pseudohyphal growth, invasive growth, phenotypic switching, cell differentiation, morphogenesis, the mitotic cell cycle, response to basic pH, regulation of fatty acid anabolism, and negative regulation of dipeptide transport. It localizes to the nucleus, cytoplasm, chromatin, and transcription repressor complex. The gene is linked to candidiasis and has been studied in Mus musculus. Associations with carbon source utilization, sporulation, nutrient uptake, fermentative growth, anaerobic growth, lifespan, and resistance to desiccation, hyperosmotic stress, and UV have been reported.