UBI — Candida albicans

Summary

Candida albicans UBI4 (UBI) encodes a ubiquitin family protein with ubiquitin-like domains, annotated as having enzyme inhibitor activity, protein tag function, and as a structural constituent of the ribosome. The gene is associated with protein ubiquitination, modification-dependent proteolysis, and the proteasomal pathway, as well as cellular responses to stress, heat, and glucose. UBI4 is associated with hyphal growth, filamentous growth, phenotypic switching, cell wall assembly, cell morphogenesis, protein secretion, the glyoxylate cycle, and modulation of the mitotic cell cycle and meiosis-specific transcript degradation. The protein localizes to the cytosolic ribosome, cytoplasm, nucleus, and plasma membrane. Phenotypic associations include abnormal mitophagy and micronucleophagy, decreased colony sectoring, absent oxidative stress resistance and alkaline pH resistance, premature apoptosis, altered cell cycle progression, and delayed carbon source utilization. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.