cdc11 — Candida albicans

Summary

C3_07110W_A (cdc11) in Candida albicans chromosome 3 encodes a protein with adenylyl cyclase activity and signaling adaptor activity, containing leucine-rich repeat domains. The gene is associated with cAMP anabolism, quorum sensing, biofilm formation, hyphal growth, filamentous growth, invasive growth, mating, and morphogenesis. It is linked to the regulation of mitotic cytokinesis, activation of mitotic division septum assembly, the septation initiation network (SIN), nuclear division, exocytosis, intracellular signal transduction, and mitosis. The encoded product localizes to the SIN/MEN signaling complex, the outer plaque of the mitotic spindle pole body, the meiotic and mitotic spindle pole bodies, and the cytoplasm. Related genes in other species link the family to adenylyl cyclase activity (EC 4.6.1.1).