CLR6 — Candida albicans

Summary

CLR6 (also known as RPD31) on Candida albicans chromosome 3 encodes a histone deacetylase with NAD-independent activity, specifically deacetylating histone H4 at lysines K5, K8, K12 and K16, and histone H3 at K9 and K14. The product belongs to the His_deacetylse_1 domain family and is a component of multiple chromatin-modifying complexes including the HDA1, Rpd3S, SHREC, SET3C and Clr6-LE complexes. CLR6 is associated with filamentous growth regulation in response to pH, starvation and biotic stimuli, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, phenotypic switching, and epigenetic downregulation of gene expression. The gene has been linked to abnormal biofilm formation, altered cell cycle progression rates, defective mating-type switching, and changes in flocculation, sporulation and pheromone sensitivity. Related genes in other species connect it to acid sensitivity.