TPX1 — Candida albicans

Summary

Candida albicans TPX1 (TSA1B) on chromosome 3 encodes a thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) with peroxidase, protein-disulfide reductase, and MAP kinase scaffold activities. The protein contains a peroxiredoxin AhpC/TSA domain and thioredoxin-like fold. TPX1 is associated with cellular redox homeostasis, response to and detoxification of hydrogen peroxide, programmed cell death, filamentous growth in response to chemical stimuli, host invasion and interaction, immune response, cell wall biogenesis, asexual reproduction, and sphingolipid and GMP anabolism. It localizes to the cytoplasm, nucleus, and hyphal cell wall. The gene is associated with oxidative stress resistance, adhesion, apoptosis, cell cycle progression, mitotic recombination, chromosome segregation, and UV resistance. Related genes in other species connect the peroxiredoxin family to oxidative stress response and genome stability.