GPD3 — Candida albicans

Summary

C3_06870W_A (GPD3, also known as TDH3) encodes a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with NAD+ and NADP binding activity, classified as EC 1.2.1.12. In Candida albicans, GPD3 is associated with glycolytic process, gluconeogenesis, methylglyoxal anabolism, ROS metabolic process, zinc import, amino acid breakdown, and cell-cell signaling. It is linked to adhesion of symbiont to host, cell-matrix adhesion, quorum sensing, immune evasion, and perturbation of host immune response. The protein localizes to the symbiont cell surface, yeast-form cell wall, hyphal cell wall, extracellular vesicle, and fungal biofilm matrix. Phenotypic associations include recovery from pheromone-induced cell cycle arrest, spindle morphology, gamma ray resistance, mitotic cell cycle, anaerobic growth, colony color, desiccation resistance, adhesion, X ray resistance, polyploidy, pexophagy, silencing, chemical compound excretion, fermentative growth, critical cell size at start, pheromone-induced cell cycle arrest, nuclear import, ionic stress resistance, and UV resistance. Studies of related genes in other species connect the family to potassium concentration.