MRR1 — Candida albicans

Summary

C3_05920W_A (MRR1) on Candida albicans chromosome 3 encodes a Zn2Cys6 DNA-binding transcription factor with both activator and repressor activity. The gene is associated with positive regulation of cellular response to drug, pentose breakdown, and regulation of filamentous growth in response to biotic stimulus. MRR1 is linked to cellular response to hypoxia and heat, TOR signaling, oxidative phosphorylation, sterol anabolism, and single-species biofilm formation on inanimate substrates. It is also connected to phagocytosis, cell-substrate adhesion, mitotic recombination, and interaction with host. The protein localizes to the nucleus and membrane. Studies of related genes in other species link the MRR1 family to reduced virulence and disseminated candidiasis.