AHR1 — Candida albicans

Summary

C3_06000W_A (AHR1) on chromosome 3 of Candida albicans encodes a Zn2Cys6 DNA-binding domain transcription factor with DNA-binding transcription activator activity, sequence-specific DNA binding, and zinc binding. This nuclear and membrane-associated protein is linked to response to hypoxia, regulation of filamentous growth in response to biotic stimulus, cell adhesion and biofilm formation, phenotypic switching, invasive growth under glucose limitation, cell size control, and negative regulation of the G1/S cell cycle transition. AHR1 is also associated with amino acid breakdown, host invasion, IL-1 production, and biological processes involved in symbiotic interaction. The gene has been connected to disseminated candidiasis in humans. Related genes in other species, such as atnE, provide additional family-level context for these associations.