CTA4 — Candida albicans

Summary

CTA4 (C3_05930W_A) in Candida albicans chromosome 3 encodes a Zn2Cys6 DNA-binding transcription factor with RNA polymerase II-specific transcription activator activity. The protein localises to both the nucleus and membrane. CTA4 is associated with positive regulation of cellular response to drug, response to nitrosative stress, and pentose breakdown. It is linked to regulation of filamentous growth, including both positive and negative regulation of growth as a thread of attached cells, as well as regulation of filamentous growth in response to biotic stimulus. The gene is associated with mating-type switching, sexual reproduction, single-species biofilm formation on inanimate substrate, cell-substrate adhesion, sulfate assimilation, interaction with host, and cellular response to heat. Related genes in other species are linked to reduced virulence and disseminated candidiasis.