ABCA — Candida albicans

Summary

C3_05220W_A (ABCA, also known as CDR1) in Candida albicans encodes an ATP-binding cassette (ABC) transporter of the PDR/CDR subfamily, with NTPase activity and demonstrated azole, fluconazole, and xenobiotic transmembrane transporter activity, as well as estradiol and corticosterone binding. It is associated with hormone transport, aminophospholipid translocation, membrane depolarization, reactive oxygen species anabolism, and responses to brefeldin A, farnesol, and progesterone. The protein localizes to the plasma membrane, membrane, vacuolar lumen, and extracellular vesicles. Phenotypic associations link ABCA to abnormal small molecule transport, vacuolar distribution, cell cycle progression, pseudohyphal growth, shmoo formation, replicative and chronological lifespan, sporulation rate, and decreased utilization of sulfur sources. Related genes in other species connect the family to traits such as plant height, leaf number, root length, and drought tolerance.