CASB — Candida albicans

Summary

C3_05190C_A (CASB, also known as MCA1) in Candida albicans encodes a metacaspase, a calcium-dependent cysteine-type endopeptidase with thiol endopeptidase activity. This gene is associated with programmed cell death and the apoptotic process, as well as responses to farnesol, heat, and oxidative stress. It is linked to biofilm formation, quorum sensing, cytoskeleton organization and its regulation, cell cycle modulation, translation, and protein quality control. Associations also include polyamine, glucan, mycose, and sphingolipid anabolism. The protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal carbon source utilization, cell cycle progression alterations, increased necrotic cell death, abnormal pseudohyphal growth, budding, flocculation, colony shape, and vesicle distribution, as well as changes in prion inheritance, polyploidy, and sporulation.