TEC1 — Candida albicans

Summary

C3_04530C_A (TEC1) on Candida albicans chromosome 3 encodes a transcription factor with DNA-binding transcription activator activity, RNA polymerase II-specific. The gene is associated with granuloma formation, mating behavior, germ tube formation, tube formation, phialide development, conidiophore development, asexual sporulation, autolysis, cell aggregation, phagocytosis, and regulation of single-species biofilm formation on inanimate substrates. It is linked to positive regulation of phialide development, conidium formation, and asexual sporulation, as well as upregulation of filamentous growth and mating projection assembly. The encoded protein localizes to the nucleus, chromatin, and transcription regulator complex. TEC1 is also connected to candidiasis and disseminated candidiasis in mouse models, and to oxidative stress response. Studies of related genes in other species link the family to developmental processes.