SFP1 — Candida albicans

Summary

C3_04860W_A (SFP1, CaSFP1) in Candida albicans encodes a protein with C2H2 zinc-finger domains and DNA-binding transcription activator activity specific for RNA polymerase II. The gene is associated with positive regulation of ribosome biogenesis, cell adhesion involved in biofilm formation, secretion by cell, positive regulation of ribosomal protein gene transcription by RNA polymerase II, innate immunity, negative regulation of G1/S transition of mitotic cell cycle, cell size control, G1 phase, cell wall biogenesis, protein secretion, TOR signaling, cell adhesion, response to oxidative stress, biofilm formation, cellular response to oxidative stress, hyphal growth, negative regulation of transcription by RNA polymerase II, and secretion. It localizes to the cytoplasm, cytosol, and nucleus. SFP1 is associated with numerous phenotypes including abnormal filamentous growth, altered mating type switching, increased polyploidy, increased alkaline pH resistance, increased critical cell size at the G1 checkpoint, increased survival in stationary phase, and abnormal cell cycle progression through G2/M. Related genes in other species link the family to acid sensitivity and mitophagy regulation.