ADE2 — Candida albicans

Summary

C3_04520C_A (ADE2) on Candida albicans chromosome 3 encodes a phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21), an enzyme that binds ATP and metal ions and belongs to the PurE and PurK domain families. This gene is associated with purine and adenine biosynthesis, de novo IMP biosynthesis, carotene anabolism, cell pH elevation, germ tube formation, biofilm formation, glucose metabolism, translation initiation, tRNA processing, cell cycle progression, homologous recombination, and non-homologous end joining. The encoded protein localises to the cytosol. ADE2 has been linked to candidiasis and to numerous phenotypes including increased apoptosis, decreased gamma ray resistance, increased mutation frequency, decreased autophagy, abnormal cell shape and budding, decreased cell size, altered lipid particle morphology, decreased sporulation, and increased resistance to enzymatic treatment. Studies of related genes in other species connect it to abnormal colony color and loss of pathogenicity.