AIN1 — Candida albicans

Summary

C3_04470W_A (AIN1, also known as PKC1) on Candida albicans chromosome 3 encodes a protein kinase C with novel protein kinase C activity, classified as EC 2.7.11.13, and possesses lipid-binding, protein serine/threonine kinase, ATP-binding, and zinc-binding activities. The gene is associated with the positive regulation of filamentous growth, cell integrity MAPK cascade, and mitotic cytokinesis site selection, as well as cellular response to cold, quorum sensing, phagocytosis, and regulation of cell shape and beta-glucan anabolism. It is linked to cell cycle progression, virulence, thermotolerance, hypoosmotic stress resistance, alkaline pH resistance, sporulation efficiency, and pheromone response. The protein localizes to the actomyosin contractile ring, division septum, cell tip, stress granule, and site of polarized growth. Related genes in other species link the family to cell wall integrity and stress responses.