BSC1 — Candida albicans

Summary

C3_02300W_A (BSC1, also known as FGR23) on chromosome 3 of Candida albicans encodes a protein of the flocculin family, a cell-surface adhesion. The gene is associated with a wide range of biological processes, including flocculation, biofilm formation, cell adhesion, filamentous growth, mating, pheromone response, response to oxidative stress, cellular response to starvation, fermentation, secretion, morphogenesis, signal transduction, cell growth, and TNF production. It is localized to the plasma membrane and the side of the membrane. Phenotypic associations link BSC1 to abnormal or absent biofilm formation and flocculation, increased adhesion and mating efficiency, increased rate of entry into G0 phase, premature meiosis and G1/S transition, delayed cytokinesis, decreased budding rate, increased polyploidy, and absent toxin, osmotic stress, and oxidative stress resistance. Studies of related genes in other species connect the family to beta-glucan and polysaccharide content.