CDS1 — Candida albicans

Summary

C3_03810W_A (CDS1, also known as RAD53) on chromosome 3 of Candida albicans encodes a dual-specificity protein kinase with serine/threonine and tyrosine kinase activities, classified as EC 2.7.12.1, and contains a forkhead-associated (FHA) domain and a protein kinase domain. The gene is associated with DNA damage response signaling, telomere maintenance, and deoxyribonucleoside triphosphate biosynthesis, as well as positive regulation of meiotic recombination and filamentous growth in response to chemical stimuli. It is linked to cell cycle progression, particularly increased G1 phase and decreased S and G2 phase rates, and to phenotypes including absent X-ray resistance, increased gamma ray resistance, and altered sporulation efficiency. The protein localizes to the cellular bud neck, nuclear membrane, and vacuolar membrane, and is connected to biofilm formation, invasive growth regulation under glucose limitation, and glutathione metabolism. Studies of related genes in other species link the family to loss of pathogenicity and cell cycle checkpoints.