NUO2 — Candida albicans

Summary

NUO2 (C3_02940C_A) on chromosome 3 of Candida albicans encodes a protein with an NADH_Ub_cplx-1_21kDa domain and ubiquinone reductase and redox activity. The protein localises to the mitochondrial inner membrane. NUO2 is associated with mitochondrial complex I assembly, electron transport chain, gluconeogenesis, nucleotide and mannan anabolism, cell cycle, S phase, mitotic cell cycle, cell size control, cell growth, morphogenesis, hyphal growth, biofilm formation, and innate immunity processes including cytokine production, IL22 production, and phagocytosis. Related genes in other species encode NADH-ubiquinone oxidoreductase subunits linked to respiratory complex I function.