SAP8 — Candida albicans

Summary

C3_02510C_A (SAP8) in Candida albicans chromosome 3 encodes a member of the aspartic peptidase A1 family, specifically an aspartic endopeptidase (EC 3.4.23.24) with metal-binding capability. The gene is associated with hyphal growth, germ tube formation, biofilm formation, adhesion to host, and morphogenesis. It is linked to proteolysis, protein processing, secretion, and fungal-type cell wall organization, as well as perturbation of host immune response, IL-8 production, and transepithelial migration of the symbiont in the host. The product localizes to the extracellular, fungal-type cell wall, and extracellular vesicles. Studies of related genes in other species link this gene family to altered virulence, including hypervirulence and reduced pathogenicity, and to candidiasis.